What are the best longevity supplements in 2026?

Short Answer: Based on current evidence, the most promising longevity compounds are: rapamycin (strongest lifespan data), metformin (TAME trial), NMN/NR (NAD+ restoration), senolytics (D+Q/fisetin), and spermidine (autophagy induction).

Evidence Level: moderate

Detailed Answer

Ranking by strength of lifespan extension evidence: (1) Rapamycin — 10-25% lifespan extension in mice (ITP, multiple studies), the most replicated result; PEARL human trial underway. (2) Metformin — extensive epidemiological data showing lower all-cause mortality in diabetic patients vs. non-diabetic controls; TAME trial testing prospectively. (3) NMN/NR — restores NAD+ levels that decline ~50% by age 60; multiple human trials showing NAD+ elevation; lifespan data in mice is mixed. (4) Senolytics (D+Q, fisetin) — clear senescent cells; healthspan extension in mice; human trials in multiple age-related diseases. (5) Spermidine — induces autophagy; epidemiological data links dietary spermidine to cardiovascular health; small human trials show cognitive benefit. Other notable compounds: sulforaphane (Nrf2), resveratrol (sirtuins), alpha-ketoglutarate, urolithin A (mitophagy). No supplement replaces exercise, sleep, and nutrition.

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