Niclosamide and Stomach Cancer: Latest Research 2026

By Insight Swarm Research Team, Medical Advisor: Nikhil Joshi, MD, FRCPC

Niclosamide and Stomach Cancer: Latest Research 2026

This page summarizes the current state of scientific research on Niclosamide in the context of Stomach Cancer as of 2026. The field evolves rapidly — this is a research summary, not medical advice. Consult your oncologist for personalized guidance.

Compound Overview

Niclosamide (Antiparasitic / Salicylamide) — FDA-approved for intestinal tapeworm; not approved for cancer

Mechanism of action: Inhibits Wnt/β-catenin, Notch, mTOR, STAT3, and NF-κB signaling; uncouples mitochondrial OXPHOS

Current evidence level: Preclinical + Phase I trials; bioavailability challenges being addressed

2026 Research Landscape

Direct research on Niclosamide specifically for Stomach Cancer remains limited as of 2026, though the mechanistic connections continue to be explored in laboratory settings.

Key areas researchers are currently examining include:

  • Mechanistic studies: Understanding precisely how Niclosamide affects the biological pathways involved in Stomach Cancer progression
  • Safety characterization: Defining appropriate doses and monitoring protocols if clinical use is considered
  • Biomarker identification: Finding measurable indicators that could predict which patients might respond
  • Screening studies: Preclinical models are still being used to establish whether clinical investigation is warranted

Where to Find the Most Current Research

To access the latest peer-reviewed publications:

  • PubMed: Search "(Niclosamide[tiab]) AND (Stomach Cancer[tiab])" at pubmed.ncbi.nlm.nih.gov
  • ClinicalTrials.gov: Search for active and completed trials with Niclosamide keywords
  • Google Scholar: Sort by date for most recent publications

Research Gaps

The most significant gaps in the Niclosamide + Stomach Cancer research landscape as of 2026 include: lack of large Phase III randomized trials, limited long-term safety data in Stomach Cancer patients, and absence of biomarker-selected patient populations who might benefit most.

Medical Disclaimer: This page summarizes published research and is not medical advice. Never start, stop, or change any treatment based on information found online. Always consult qualified healthcare professionals before making treatment decisions.

Get a personalized AI-generated research report at insightswarm.ai.

Frequently Asked Questions

What are the most recent studies on Niclosamide for Stomach Cancer?

The most current peer-reviewed studies can be found on PubMed (pubmed.ncbi.nlm.nih.gov). Search for 'Niclosamide Stomach Cancer' filtered to the last 2 years. The current evidence level is: Preclinical + Phase I trials; bioavailability challenges being addressed.

Are there any 2025-2026 clinical trials for Niclosamide in Stomach Cancer?

Check ClinicalTrials.gov with 'Niclosamide' as intervention and 'Stomach Cancer' as condition. Filter by 'Recruiting' status for currently enrolling trials. Your oncologist can advise whether any trials may be appropriate for your specific situation.

Has the evidence for Niclosamide in Stomach Cancer changed recently?

The field evolves rapidly. The current evidence classification is: Preclinical + Phase I trials; bioavailability challenges being addressed. For the most up-to-date summary, Insight Swarm generates personalized research reports that incorporate the latest publications specific to your case.