BDNF (Brain-Derived Neurotrophic Factor)

Category: biomarker

A key neurotrophin that supports neuron survival, synaptic plasticity, and neurogenesis. Reduced BDNF levels are associated with multiple neurodegenerative diseases.

Mechanism Detail

BDNF binds TrkB receptors, activating PI3K/Akt (survival), MAPK/ERK (differentiation), and PLCγ (synaptic plasticity) pathways. Exercise is the most potent natural BDNF inducer. Val66Met polymorphism affects BDNF secretion and is a risk modifier for neurodegenerative diseases.

Clinical Status

No BDNF-based therapeutics approved. Exercise protocols, photobiomodulation, and certain nutraceuticals increase BDNF. Serum BDNF is used as a research biomarker but not clinically validated.

Relevant Diseases

• ALS
• Alzheimer's Disease
• Parkinson's Disease

Relevant Therapies

• Lifestyle Interventions
• Peptides

Related Terms

• TrkB receptor
• Neuroplasticity
• Exercise
• Photobiomodulation