Coenzyme Q10 (Ubiquinol)

Category: compound

A mitochondrial electron transport chain cofactor and potent lipid-soluble antioxidant. Studied for neuroprotection in ALS and Parkinson's disease.

Mechanism Detail

CoQ10 serves as an electron carrier between Complex I/II and Complex III of the mitochondrial electron transport chain. As ubiquinol (reduced form), it scavenges lipid peroxyl radicals and regenerates vitamin E. Supports ATP production in energy-demanding neurons.

Clinical Status

Phase II trial in ALS showed no significant benefit at tested doses. Ongoing research explores higher doses and combination protocols. Well-studied safety profile.

Relevant Diseases

• ALS
• Parkinson's Disease

Relevant Therapies

• Nutraceuticals

Related Terms

• Mitochondrial dysfunction
• Oxidative stress
• NAD+
• Electron transport chain