Curcumin (BCM-95 / Theracurmin)

Category: compound

A polyphenol from turmeric with anti-inflammatory, antioxidant, and potential anti-amyloid properties. Bioavailability-enhanced formulations are studied for neurological conditions and cancer.

Mechanism Detail

Curcumin inhibits NF-κB signaling, reducing inflammatory cytokine production. It binds amyloid-beta fibrils (relevant to Alzheimer's), modulates epigenetic enzymes (HATs, HDACs), and induces apoptosis in cancer cells through multiple pathways including PI3K/Akt inhibition.

Clinical Status

Multiple clinical trials completed. Bioavailability remains the primary challenge. Lipid-formulated versions (BCM-95, Theracurmin) show improved absorption.

Relevant Diseases

• Alzheimer's Disease
• Stage IV Cancer

Relevant Therapies

• Nutraceuticals

Related Terms

• NF-κB
• Polyphenols
• Anti-inflammatory
• Amyloid-beta