EGCG (Epigallocatechin Gallate)

Category: compound

The primary polyphenol in green tea with anti-amyloid, anti-cancer, and neuroprotective properties through multiple signaling pathways.

Mechanism Detail

EGCG inhibits amyloid-beta and alpha-synuclein fibril formation by redirecting aggregation toward non-toxic oligomers. It inhibits telomerase, VEGF, and matrix metalloproteinases in cancer. EGCG chelates iron, modulates MAPK/ERK signaling, and activates AMPK. It also inhibits DNA methyltransferase (epigenetic modulation).

Clinical Status

SuniDARE trial for Alzheimer's. Phase II trials for various cancers. Hepatotoxicity at high doses is a concern. Bioavailability improved by lipid nanoparticle formulations.

Relevant Diseases

Relevant Therapies

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