Ivermectin

Category: compound

A macrocyclic lactone with antiparasitic, anti-inflammatory, and potential anti-cancer properties through multiple mechanisms including P-glycoprotein modulation.

Mechanism Detail

Ivermectin modulates chloride ion channels, inhibits PAK1 kinase activity, blocks Wnt/β-catenin signaling, and induces mitochondrial dysfunction in cancer cells. It also modulates P-glycoprotein, potentially reversing multidrug resistance in chemotherapy-resistant tumors.

Clinical Status

Preclinical evidence for anti-cancer effects. Small clinical studies underway. FDA-approved only as an antiparasitic.

Relevant Diseases

Relevant Therapies

Related Terms