Mebendazole

Category: compound

A benzimidazole anthelmintic studied for anti-cancer and anti-inflammatory properties. Has better CNS penetration than fenbendazole.

Mechanism Detail

Mebendazole binds β-tubulin (isoform-selective), disrupting microtubule dynamics. It also inhibits VEGF-mediated angiogenesis, modulates NF-κB, and induces apoptosis through BCL-2 family modulation. Its ability to cross the blood-brain barrier makes it relevant for CNS applications.

Clinical Status

Phase I/II trials for glioblastoma and other CNS tumors. Repurposing studies for colorectal cancer. Well-established safety profile from decades of antiparasitic use.

Relevant Diseases

Relevant Therapies

Related Terms