Metformin

Category: compound

A biguanide antidiabetic drug being repurposed for cancer prevention and longevity through AMPK activation and metabolic modulation.

Mechanism Detail

Metformin inhibits mitochondrial Complex I, increasing the AMP/ATP ratio and activating AMPK. This suppresses mTOR signaling, reduces hepatic glucose production, enhances insulin sensitivity, and inhibits cancer cell proliferation through multiple pathways including NF-κB suppression and HIF-1α inhibition.

Clinical Status

TAME (Targeting Aging with Metformin) trial ongoing. Epidemiological data shows reduced cancer incidence in diabetic patients on metformin. Multiple cancer adjunctive trials underway.

Relevant Diseases

Relevant Therapies

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