Spermidine

Category: compound

A natural polyamine that induces autophagy and has demonstrated lifespan extension in multiple organisms. Found in wheat germ, soybeans, and aged cheese.

Mechanism Detail

Spermidine induces autophagy through inhibition of EP300 acetyltransferase, leading to hypoacetylation of autophagy-related proteins. It also inhibits the NLRP3 inflammasome, promotes mitophagy (clearance of damaged mitochondria), and enhances proteasomal degradation of misfolded proteins.

Clinical Status

SmartAge trial showed improved memory in older adults with subjective cognitive decline. Epidemiological studies correlate higher dietary spermidine with reduced cardiovascular and neurological disease. Well-tolerated as supplement.

Relevant Diseases

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