Thymosin Alpha-1 (Tα1)

Category: compound

A thymic peptide hormone that modulates T-cell maturation and dendritic cell function. Used as an immune adjuvant and studied for cancer immunotherapy support.

Mechanism Detail

Tα1 activates toll-like receptors (TLR2, TLR9) on dendritic cells, promoting antigen presentation. It drives T-cell maturation from progenitor to mature effector cells, enhances NK cell cytotoxicity, and supports immune reconstitution during chemotherapy-induced immunosuppression.

Clinical Status

Approved in 35+ countries for hepatitis B/C and as an immune adjuvant. Clinical trials for cancer immunotherapy support show improved immune function during chemotherapy. Not FDA-approved in the US.

Relevant Diseases

Relevant Therapies

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