Hesperidin for ALS
Also known as: Citrus bioflavonoid, Vitamin P
Hesperidin's anti-excitotoxic and anti-inflammatory properties may support motor neuron viability in ALS.
Mechanism of Action
Hesperidin reduces glutamate excitotoxicity, suppresses neuroinflammation through NF-κB inhibition, and promotes neurotrophic factor expression for motor neuron support.
General mechanism: Citrus flavanone glycoside. AChE inhibitor, BDNF/TrkB activator, NF-κB inhibitor, Nrf2 activator. Crosses BBB.
Current Evidence
Preclinical neuroprotection data. No ALS-specific studies.
Clinical Status: Preclinical. Available as supplement.
Safety Profile
Very safe. Naturally present in citrus fruits. Well-tolerated. No significant drug interactions at supplement doses.
Key Research Questions
- Can hesperidin reduce excitotoxic motor neuron damage?
- Does hesperidin combination with riluzole provide additive neuroprotection?