Taurine for ALS
Also known as: 2-aminoethanesulfonic acid
Taurine is an inhibitory neuromodulator that reduces excitotoxicity and supports motor neuron osmotic stress tolerance.
Mechanism of Action
Taurine activates glycine and GABA-A receptors, providing inhibitory tone against glutamate excitotoxicity. It acts as an osmoregulator in motor neurons, maintains calcium homeostasis, and serves as a mitochondrial matrix buffer. Taurine also stabilizes cell membranes through phospholipid interactions.
General mechanism: Amino sulfonic acid. GABAergic/glycinergic modulator, osmoregulator, mitochondrial buffer, membrane stabilizer, antioxidant.
Current Evidence
CSF taurine levels are altered in ALS. Preclinical models show motor neuron protection. No definitive clinical trials. High safety margin allows investigation of high doses.
Clinical Status: Preclinical for ALS. Available as supplement. Very high safety margin.
Safety Profile
Extremely safe. Naturally abundant in body. No toxicity reported even at very high doses (6g+/day). Well-tolerated.
Key Research Questions
- Can taurine's anti-excitotoxic effects complement riluzole in ALS?
- Does taurine supplementation normalize CSF taurine levels in ALS?