Apigenin for Alzheimer's Disease
Also known as: 4',5,7-trihydroxyflavone, Chamomile extract
Apigenin inhibits CD38 to preserve NAD+ levels and reduces neuroinflammation — addressing two key AD pathological mechanisms.
Mechanism of Action
Apigenin is a potent CD38 inhibitor, preserving cellular NAD+ for SIRT1/3-dependent neuroprotective functions. It also inhibits NF-κB, reduces microglial activation, promotes BDNF expression, and directly inhibits BACE1 for reduced amyloid production.
General mechanism: Flavone. CD38 inhibitor (NAD+ preservation), NF-κB suppressor, CK2/PI3K inhibitor, BDNF promoter.
Current Evidence
Preclinical AD models show cognitive improvement and reduced pathology. CD38 inhibition is an emerging NAD+ preservation strategy. Human studies limited to anxiety/sleep applications.
Clinical Status: Preclinical for AD. Available as supplement (chamomile extract).
Safety Profile
Very safe. Naturally present in diet. Sedative at high doses (chamomile effect). No significant drug interactions.
Key Research Questions
- Can apigenin's CD38 inhibition maintain brain NAD+ in aging and AD?
- Does apigenin cross the BBB at sufficient concentrations?