Molecular Hydrogen (H₂) for Alzheimer's Disease
Also known as: H2 therapy, Hydrogen water, Hydrogen gas inhalation
H₂'s selective antioxidant properties address hydroxyl radical damage in AD neurons without disrupting beneficial redox signaling.
Mechanism of Action
H₂ neutralizes •OH radicals generated by iron-mediated Fenton reactions in AD brain (iron accumulates around amyloid plaques). It reduces oxidative DNA damage, protects mitochondrial function, and modulates microglial activation without eliminating beneficial H₂O₂ signaling.
General mechanism: Selective antioxidant gas. Scavenges •OH and ONOO⁻ while preserving signaling ROS. Nrf2 activator, NF-κB inhibitor.
Current Evidence
Preclinical AD models show improved cognition and reduced oxidative damage. Small human studies with hydrogen water show improved cognitive scores. Larger trials needed.
Clinical Status: Preclinical and small clinical studies positive. Available as hydrogen water.
Safety Profile
Extremely safe. No toxicity at therapeutic concentrations. Non-flammable at <4% concentration. No side effects reported.
Key Research Questions
- Can long-term hydrogen water consumption prevent cognitive decline?
- Does H₂ reduce iron-Fenton chemistry damage in AD brain?