Quercetin for Alzheimer's Disease
Also known as: Quercetin dihydrate
Quercetin's senolytic and anti-inflammatory properties target cellular senescence — an emerging driver of Alzheimer's neurodegeneration.
Mechanism of Action
As a senolytic (with dasatinib), quercetin selectively clears senescent neurons and glia that produce inflammatory SASP factors driving neurodegeneration. Independently, quercetin inhibits PI3K, activates sirtuins, suppresses NF-κB and NLRP3 inflammasome, and directly inhibits amyloid-beta aggregation through aromatic ring stacking.
General mechanism: Flavonoid polyphenol. PI3K inhibitor, sirtuin activator, NF-κB/NLRP3 suppressor. Senolytic (with dasatinib) through BCL-2/BCL-XL disruption.
Current Evidence
Dasatinib + quercetin senolytic combination tested in Phase I/II for Alzheimer's (SToMP-AD trial). Early results suggest brain senescent cell clearance. Quercetin alone shows anti-amyloid effects in preclinical models. Bioavailability enhanced by lipid formulations.
Clinical Status: Phase I/II (SToMP-AD senolytic trial). Available as supplement. Senolytic approach in early clinical investigation.
Safety Profile
Very safe as supplement. Dasatinib combination has higher side effect potential (fluid retention, cytopenias). Well-tolerated at standard supplement doses.
Key Research Questions
- Can senolytic therapy clear senescent neurons and glia in Alzheimer's brain?
- What is the optimal senolytic treatment interval (monthly? quarterly?) for sustained benefit?
- Does quercetin's anti-amyloid activity complement senolytic effects?
Frequently Asked Questions
Is quercetin a senolytic?
Yes. Quercetin combined with dasatinib is the most-studied senolytic combination. The landmark 2018 study (Xu et al., Nature Medicine) showed this combination selectively eliminates senescent cells and extends healthspan in mice. Human pilot trials show reduced senescent cell burden.
Quercetin dosage as senolytic
Senolytic protocols typically use quercetin 1000mg + dasatinib 100mg for 3 consecutive days per month (intermittent dosing). Continuous daily quercetin (500-1000mg) may provide antioxidant benefits but does not achieve senolytic concentrations.