Taurine for Alzheimer's Disease
Also known as: 2-aminoethanesulfonic acid
Brain taurine declines with aging and AD, and supplementation may support synaptic function and reduce neuroinflammation.
Mechanism of Action
Taurine modulates GABAergic and glycinergic neurotransmission, supports synaptic plasticity, reduces amyloid-beta-induced calcium overload, and activates anti-inflammatory pathways. It also supports retinal ganglion cell function (visual deficits are common in AD).
General mechanism: Amino sulfonic acid. GABAergic/glycinergic modulator, osmoregulator, mitochondrial buffer, membrane stabilizer, antioxidant.
Current Evidence
A landmark 2023 study (Singh et al., Science) showed taurine extends lifespan and healthspan in multiple species. Brain taurine supplementation improved cognition in aged mice. Human AD trials planned.
Clinical Status: Major longevity study published. AD-specific trials emerging.
Safety Profile
Extremely safe. Naturally abundant in body. No toxicity reported even at very high doses (6g+/day). Well-tolerated.
Key Research Questions
- Can taurine supplementation reverse age-related cognitive decline?
- Does taurine address the GABAergic deficit in AD?