AI-Powered Glioblastoma Research
GBM is the most aggressive primary brain tumor. AI agents research blood-brain barrier penetration strategies, immunotherapy, tumor-treating fields, and novel compounds.
Standard of Care
Surgical resection, temozolomide + radiation (Stupp protocol), tumor-treating fields (Optune), bevacizumab.
Prevalence
~13,000 new GBM diagnoses per year in the US.
Five-Year Survival
~6.8% overall. Median survival ~15 months with standard treatment.
Key Mutations
- IDH1/2
- MGMT promoter methylation
- EGFRvIII
- PTEN loss
- TERT promoter
Key Pathways
- egfr-signaling
- pi3k-akt-mtor
- vegf-angiogenesis
Clinical Trial Focus
CAR-T for GBM, oncolytic virus (DNX-2401), convection-enhanced delivery, neoantigen vaccines.