AI-Powered Pancreatic Cancer Research
Pancreatic cancer has the lowest survival rate of all major cancers. AI agents research stromal-targeting strategies, KRAS inhibitors, and immunotherapy combinations.
Standard of Care
FOLFIRINOX, gemcitabine/nab-paclitaxel, surgical resection (Whipple) for eligible patients.
Prevalence
~64,000 new diagnoses per year in the US. 5th leading cause of cancer death.
Five-Year Survival
Stage IV: ~3%. All stages combined: ~12%.
Key Mutations
- KRAS (>90%)
- TP53
- CDKN2A
- SMAD4
- BRCA1/2
Key Pathways
- kras-mapk
- tgf-beta-signaling
- hedgehog-signaling
Clinical Trial Focus
KRAS G12D inhibitors, stromal disruption agents, mRNA vaccines (personalized neoantigen), oncolytic viruses.