AI-Powered Prostate Cancer Research
mCRPC represents the most challenging phase of prostate cancer. AI agents research PSMA-targeted therapies, PARP inhibitors, and novel androgen receptor approaches.
Standard of Care
Androgen deprivation + novel hormonal agents (enzalutamide, abiraterone), docetaxel/cabazitaxel, PSMA-targeted radioligand (Lu-177 PSMA-617), PARP inhibitors (BRCA+).
Prevalence
~300,000 new prostate cancer diagnoses per year in the US. ~35,000 deaths.
Five-Year Survival
Stage IV: ~32%. With PSMA-targeted therapy: improving.
Key Mutations
- BRCA1/2
- ATM
- CDK12
- PTEN loss
- AR amplification
- MSI-H/dMMR
Key Pathways
- androgen-receptor-signaling
- dna-damage-repair
- pi3k-akt-mtor
Clinical Trial Focus
PSMA-targeted bispecifics, PSMA-CAR-T, bipolar androgen therapy, CDK12 loss-targeted immunotherapy.