AI-Powered Prostate Cancer Research

mCRPC represents the most challenging phase of prostate cancer. AI agents research PSMA-targeted therapies, PARP inhibitors, and novel androgen receptor approaches.

Standard of Care

Androgen deprivation + novel hormonal agents (enzalutamide, abiraterone), docetaxel/cabazitaxel, PSMA-targeted radioligand (Lu-177 PSMA-617), PARP inhibitors (BRCA+).

Prevalence

~300,000 new prostate cancer diagnoses per year in the US. ~35,000 deaths.

Five-Year Survival

Stage IV: ~32%. With PSMA-targeted therapy: improving.

Key Mutations

Key Pathways

Clinical Trial Focus

PSMA-targeted bispecifics, PSMA-CAR-T, bipolar androgen therapy, CDK12 loss-targeted immunotherapy.