Apigenin for Parkinson's Disease
Also known as: 4',5,7-trihydroxyflavone, Chamomile extract
Apigenin's anti-neuroinflammatory effects and NAD+ preservation target core PD pathology.
Mechanism of Action
Apigenin inhibits microglial-driven neuroinflammation, preserves NAD+ through CD38 inhibition for mitochondrial function, and reduces α-synuclein-induced oxidative stress. It also promotes BDNF expression for dopaminergic neuron support.
General mechanism: Flavone. CD38 inhibitor (NAD+ preservation), NF-κB suppressor, CK2/PI3K inhibitor, BDNF promoter.
Current Evidence
Preclinical PD models show neuroprotection. CD38 role in PD is an emerging research area. No clinical trials.
Clinical Status: Preclinical. Available as supplement.
Safety Profile
Very safe. Naturally present in diet. Sedative at high doses (chamomile effect). No significant drug interactions.
Key Research Questions
- Does apigenin's CD38 inhibition benefit PD mitochondrial function?
- Can dietary apigenin reduce PD risk?