Dihydromyricetin (DHM) for Parkinson's Disease
Also known as: DHM, Ampelopsin, Ampelopsis grossedentata extract
DHM reduces neuroinflammation and may modulate dopamine metabolism through antioxidant effects.
Mechanism of Action
DHM activates AMPK/SIRT1 pathway for mitochondrial protection, reduces NLRP3-driven neuroinflammation, and provides antioxidant protection against dopamine auto-oxidation. Its GABA modulation may also address PD anxiety.
General mechanism: Flavonoid. GABA-A positive modulator, AMPK/SIRT1 activator, NLRP3 inhibitor, PI3K/mTOR suppressor, hepatoprotective.
Current Evidence
Preclinical models show neuroprotective effects. PD-specific studies are limited.
Clinical Status: Preclinical. Available as supplement.
Safety Profile
Very safe. Well-tolerated. No significant side effects. Used traditionally in Chinese medicine.
Key Research Questions
- Can DHM address both motor and non-motor (anxiety, sleep) PD symptoms?
- Does DHM's AMPK activation benefit PD mitochondrial function?