Hesperidin for Parkinson's Disease
Also known as: Citrus bioflavonoid, Vitamin P
Hesperidin's anti-inflammatory and neurotrophic effects may protect dopaminergic neurons in Parkinson's.
Mechanism of Action
Hesperidin activates BDNF/TrkB signaling for dopaminergic neuron survival, inhibits microglial NF-κB activation, and reduces oxidative stress through Nrf2 pathway activation. It also improves cerebrovascular function.
General mechanism: Citrus flavanone glycoside. AChE inhibitor, BDNF/TrkB activator, NF-κB inhibitor, Nrf2 activator. Crosses BBB.
Current Evidence
Preclinical PD models show dopaminergic neuroprotection. Epidemiological data supports citrus consumption for PD risk reduction. No clinical trials.
Clinical Status: Preclinical. Epidemiological support from dietary studies.
Safety Profile
Very safe. Naturally present in citrus fruits. Well-tolerated. No significant drug interactions at supplement doses.
Key Research Questions
- Does regular citrus consumption reduce PD risk through hesperidin?
- Can hesperidin enhance BDNF-mediated neuroprotection in PD?