Taurine for Parkinson's Disease
Also known as: 2-aminoethanesulfonic acid
Taurine's anti-excitotoxic and mitochondrial support properties may protect dopaminergic neurons in Parkinson's.
Mechanism of Action
Taurine reduces excitotoxic calcium influx in dopaminergic neurons, stabilizes mitochondrial membrane potential, and provides osmoregulation under cellular stress. It may also modulate dopamine release and metabolism.
General mechanism: Amino sulfonic acid. GABAergic/glycinergic modulator, osmoregulator, mitochondrial buffer, membrane stabilizer, antioxidant.
Current Evidence
Preclinical PD models show neuroprotection. The Science longevity study (2023) reinvigorated interest. PD-specific trials not yet conducted.
Clinical Status: Preclinical positive. Longevity data from Science 2023 supports investigation.
Safety Profile
Extremely safe. Naturally abundant in body. No toxicity reported even at very high doses (6g+/day). Well-tolerated.
Key Research Questions
- Does taurine protect dopaminergic neurons from MPTP-like toxicity in humans?
- Can taurine improve non-motor PD symptoms?