Creatine Monohydrate for Stage IV Cancer
Also known as: Creatine
Creatine may enhance anti-tumor immune cell energy metabolism and reduce cancer-related fatigue.
Mechanism of Action
Creatine supports ATP production in tumor-infiltrating T cells and NK cells, enhancing their anti-tumor cytotoxicity. It also reduces cancer-related fatigue and preserves muscle mass during chemotherapy-induced cachexia.
General mechanism: Phosphocreatine energy buffer. ATP stabilization, mitochondrial protection, anti-apoptotic, muscle preservation.
Current Evidence
Preclinical studies show creatine-fed T cells have enhanced anti-tumor activity. Clinical trials for cancer-related fatigue show benefit. Immune-enhancing effects are an emerging area.
Clinical Status: Phase II for cancer fatigue. Immune enhancement studies preclinical.
Safety Profile
Extremely safe. Decades of safety data. GI effects at high loading doses. Water retention. Safe long-term at 3-5g/day.
Key Research Questions
- Does creatine enhance immune cell cytotoxicity against tumors?
- Can creatine supplementation reduce cancer-related cachexia and fatigue?