Molecular Hydrogen (H₂) for Stage IV Cancer
Also known as: H2 therapy, Hydrogen water, Hydrogen gas inhalation
H₂ reduces chemotherapy side effects and radiation damage to normal tissue while potentially sensitizing tumors.
Mechanism of Action
H₂ protects normal tissue from radiation and chemotherapy-induced oxidative damage while potentially enhancing tumor sensitivity through modulation of tumor redox balance. It reduces fatigue and improves quality of life during cancer treatment.
General mechanism: Selective antioxidant gas. Scavenges •OH and ONOO⁻ while preserving signaling ROS. Nrf2 activator, NF-κB inhibitor.
Current Evidence
Clinical trials show reduced radiation side effects and improved quality of life. Hydrogen inhalation during chemotherapy reduces fatigue and anorexia. Tumor sensitization effects are preclinical.
Clinical Status: Phase I/II for radiation protection. Quality-of-life improvement documented.
Safety Profile
Extremely safe. No toxicity at therapeutic concentrations. Non-flammable at <4% concentration. No side effects reported.
Key Research Questions
- Does H₂ protect normal tissue without protecting tumors from radiation?
- Can H₂ inhalation improve cancer treatment tolerability?