Numbness & Tingling
Numbness and tingling (paresthesia) can indicate peripheral neuropathy from diabetes, autoimmune conditions, chemotherapy, vitamin deficiencies, or MS. Pattern of involvement helps identify the cause.
Body System: Neurological
Related Diseases
- Autoimmune Diseases — MS demyelination, Guillain-Barré, CIDP, and small fiber neuropathy in lupus/Sjögren's cause sensory symptoms.
- Stage IV Cancer — Chemotherapy-induced peripheral neuropathy (CIPN) from taxanes, platinums, and vinca alkaloids.
Related Compounds
Frequently Asked Questions
Can chemotherapy neuropathy be treated?
Duloxetine has the strongest evidence for CIPN treatment. Acetyl-L-carnitine and alpha-lipoic acid show mixed results for prevention. Cryotherapy (frozen gloves/socks during infusion) may prevent taxane-induced neuropathy. Physical therapy and TENS can manage symptoms. Some neuropathy resolves months after treatment ends.