Unexplained Weight Loss

⚠️ Unexplained weight loss requires prompt medical evaluation to rule out malignancy.

Unintentional weight loss (>5% body weight in 6-12 months) can indicate cancer, autoimmune conditions, thyroid disorders, or metabolic diseases. Cancer cachexia — a complex metabolic syndrome — affects up to 80% of advanced cancer patients.

Body System: Systemic / Metabolic

Related Diseases

• Stage IV Cancer — Cancer cachexia drives 20-30% of cancer deaths. Tumor-derived cytokines and metabolic reprogramming cause muscle and fat wasting.
• Autoimmune Diseases — Active inflammation in RA, Crohn's, lupus can drive metabolic wasting and appetite loss.

Related Compounds

• Melatonin
• Omega-3

Frequently Asked Questions

When is weight loss a sign of cancer?

Unintentional loss of >5% body weight in 6-12 months warrants investigation. Red flags: loss of appetite, night sweats, fatigue, new lumps, persistent cough, or changes in bowel habits. GI cancers, lung cancer, and lymphoma are common causes. Basic workup includes CBC, metabolic panel, CT imaging.

What is cancer cachexia?

Cachexia is a multi-organ metabolic syndrome driven by tumor-derived inflammatory cytokines (TNF-α, IL-6). It causes skeletal muscle wasting even with adequate nutrition, distinguishing it from simple starvation. Current research targets include anamorelin (ghrelin receptor agonist), anti-IL-6 antibodies, and metabolic modulators.