EGCG (Epigallocatechin Gallate) for ALS
Also known as: Green tea extract, EGCg
EGCG's iron chelation and anti-aggregation properties may address iron dysregulation and protein misfolding in ALS motor neurons.
Mechanism of Action
EGCG chelates redox-active iron accumulating in ALS motor neurons, inhibits SOD1 and TDP-43 aggregation through amyloid remodeling, suppresses NF-κB-driven neuroinflammation, and activates Nrf2 antioxidant defense.
General mechanism: Tea catechin. Iron chelator, amyloid remodeler, EGFR inhibitor, DNMT inhibitor, Nrf2 activator, proteasome modulator.
Current Evidence
Preclinical ALS models show motor neuron protection and extended survival. The multi-target mechanism is attractive for a multifactorial disease. No ALS clinical trials.
Clinical Status: Preclinical for ALS. Established safety from other indications.
Safety Profile
Generally safe from dietary sources. Hepatotoxicity reported with concentrated supplements >800mg/day. Caffeine interactions possible.
Key Research Questions
- Can EGCG reduce TDP-43 aggregation in ALS motor neurons?
- What EGCG formulation achieves optimal CNS levels for ALS?