Hyperbaric Oxygen Therapy (HBOT) for ALS
Also known as: HBOT, HBO, Hyperbaric medicine
HBOT may support motor neuron oxygenation and reduce neuroinflammation, though evidence is very limited.
Mechanism of Action
HBOT increases spinal cord oxygenation, may reduce neuroinflammatory hypoxia, and mobilizes bone marrow stem cells. Anti-inflammatory effects through hyperoxia signaling may reduce glial activation.
General mechanism: Pressurized oxygen delivery. Hyperoxia/normoxia cycling activates HIF pathway, stem cell mobilization, angiogenesis, anti-inflammatory signaling.
Current Evidence
Very limited ALS data. Case reports suggest symptomatic benefit. Controlled studies needed. Mechanism plausible but unproven in ALS.
Clinical Status: Anecdotal. No controlled ALS trials.
Safety Profile
Generally safe. Ear/sinus barotrauma, oxygen toxicity seizures (rare). Contraindicated with untreated pneumothorax. Specialized facility required.
Key Research Questions
- Can HBOT improve spinal cord oxygenation to benefit motor neurons?
- Is HBOT safe for ALS patients with respiratory compromise?